By Dr. Paul Hrkal

The human brain is composed of over 60% fat, and for decades, clinicians and researchers have looked at the role of healthy fats—especially omega-3s—in supporting brain structure and function. A recent publication in the Journal of Alzheimer’s & Dementia (August 2025) adds an important piece to this puzzle and may help explain why women face a higher risk of dementia.

The Study at a Glance

Researchers analyzed 841 participants divided into three groups:

• 306 with diagnosed dementia
• 165 with mild cognitive impairment (MCI)
• 370 cognitively healthy controls

They examined brain fat profiles and found a striking pattern: women with dementia showed lower levels of unsaturated fatty acids—essentially omega-3s—compared to other groups. This is the first evidence hinting at a biological connection that may help explain why women experience dementia at rates estimated to be 2–3× higher than men.

Important caveat: This is a meaningful clue—not a definitive cause. Dementia is multifactorial. Hormonal changes, inflammation, lifestyle, and metabolic health likely interact with fatty-acid status.

Why This Matters for Women’s Brain Health

Because dementia processes can unfold silently over decades, early prevention is critical. These findings suggest women may have an increased need for omega-3s to maintain brain lipid balance and support neuroprotective pathways.

Omega-3s: Beyond Cholesterol

We often think of omega-3s in terms of lipids and cholesterol. However, this study points to benefits that appear independent of cholesterol levels. Omega-3s may support brain health through:

• Neuroplasticity – aiding the brain’s natural repair and remodelling
• Blood–brain barrier integrity – improving the interface between the body and the CNS
• Cellular structure – DHA is a core component of neuronal membranes
• Inflammation modulation – helping balance neuroinflammatory processes

Prevention: What You Can Do Decades Before Symptoms

Prevention consistently outperforms treatment for neurodegenerative conditions. In addition to optimizing omega-3 intake, two lifestyle lanes stand out:

1) Move Your Body—Especially with Coordination

Activities like pickleball and other racket sports are low-impact, engaging, and stimulate the cerebellum, the coordination hub of the brain. Exercise supports neuroplasticity, metabolic health, and mood—key pillars of long-term brain resilience.

2) Eat for the Brain—Tame Blood Sugar & Inflammation

Emerging research sometimes refers to Alzheimer’s-like changes as “type 3 diabetes,” highlighting the role of insulin resistance and metabolic dysfunction in the brain. Prioritize:

• Whole foods over ultra-processed options
• Low-glycemic carbohydrates and fibre-rich plants
• Quality proteins and healthy fats (including EPA/DHA)

Key Takeaways

• Women are at a higher risk for dementia; new data links this to lower brain omega-3 status in women with dementia.
• Omega-3 benefits may occur independent of cholesterol changes, via neuroplasticity and blood–brain barrier support.
• Start early: prevention begins decades before symptoms—exercise and nutrition matter.
• Work with your healthcare provider to determine the right omega-3 dosing strategy for you.

Next Steps

If you’re considering omega-3 supplementation, choose a high-quality source and consistent daily intake. Pair it with movement you enjoy and a diet designed to balance blood sugar and inflammation. These foundational habits can help protect brain health over the long term.

References & Notes

• Study referenced: Journal of Alzheimer’s & Dementia, August 2025 (women with dementia showing lower unsaturated fatty acids).
• This article is for educational purposes only and is not a substitute for personalized medical advice.

About the Author: Dr. Paul Hrkal is a naturopathic doctor focused on neurological health, metabolic optimization, and evidence-informed nutrition.